反应详情

A mixture of 2 g of 4-chloro-8-fluoroquinazoline, 1.94 g of 2-[4-(i-propyl)phenyl]ethylamine, and 1.21 g of triethylamine in 100 mL of ethanol was heated at reflux for one hour. The ethanol was removed and the remaining product was dissolved in 100 mL of methylenechloride and then washed with aqueous sodium carbonate. The organic layer was then dried and the solvent was removed. The residue was slurried in pentane. Yield: 2.4 g. M.P. 170°-172° C.

1. temperaturewas heated
2. temperatureat reflux for one hour
3. customThe ethanol was removed
4. dissolutionthe remaining product was dissolved in 100 mL of methylenechloride
5. washwashed with aqueous sodium carbonate
6. customThe organic layer was then dried
7. customthe solvent was removed