Butanethiol → HCID 13268906, compound

HRID 358437Notes

Reaction equation

HRID 358437 reaction equation
CC[O-].[Na+].[CH2:5]([SH:9])[CH2:6][CH2:7][CH3:8].Cl[CH:11]1[CH2:17][CH2:16][NH:15][C:14](=[O:18])[CH2:13][CH2:12]1>C(O)C>[CH2:5]([S:9][CH:11]1[CH2:17][CH2:16][NH:15][C:14](=[O:18])[CH2:13][CH2:12]1)[CH2:6][CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 8012ButanethiolHCID 2723922Sodium ethoxideHCID 204480515-Chloroazepan-2-one

Product 1

HCID 13268906HCID 13268906, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6.8 g (0.1 mol) of sodium ethylate and 9 g (0.1 mol) of butanethiol are initially introduced into 100 ml of ethanol, and 14.8 g (0.1 mol) of 5-chloro-azacycloheptan-2-one are added at room temperature. After the mixture has been boiled under reflux for 10 hours, the precipitated sodium chloride is filtered off under suction, the mother liquor is evaporated down in vacuo and the residue is distilled.

Workup

  1. additionare added at room temperature
  2. temperatureunder reflux for 10 hours
  3. filtrationthe precipitated sodium chloride is filtered off under suction
  4. customthe mother liquor is evaporated down in vacuo
  5. distillationthe residue is distilled

Sources & evidence

ORD record
ord-05541c90bccc4eb1a6a1c1c9232a1bfe
Source dataset
uspto-grants-1984_08
Patent number
US04468392

Reaction notes

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