反应详情

1,1-Diethyl-3-[13-(1-hydroxy-1-methyl-1-ethyl)-2,6-dimethyl- 8alpha-ergolinyl]-urea (0.5 mmol) is dissolved in 5 ml of glacial acetic acid and 0.25 g of sodium borohydride is added. After 15 minutes of stirring at room temperature, ice is added, it is made alkaline with conc. ammonia and extracted with ethyl acetate. The organic phases are dried with sodium sulfate and concentrated by evaporation, the residue is chromatographed on silica gel with dichloromethane/methanol, yield 76 mg (38% of theory).

1. additionice is added
2. extractionextracted with ethyl acetate
3. dry with materialThe organic phases are dried with sodium sulfate
4. concentrationconcentrated by evaporation
5. customthe residue is chromatographed on silica gel with dichloromethane/methanol, yield 76 mg (38% of theory)