HCID 19912998, compound → HCID 19912992, compound

HRID 358578Notes

Reaction equation

HRID 358578 reaction equation
[OH:1][CH2:2][C:3]1[CH:8]=[C:7]([NH:9][C:10](=[O:12])[CH3:11])[CH:6]=[CH:5][N:4]=1>ClCCl.O=[Mn]=O>[C:10]([NH:9][C:7]1[CH:6]=[CH:5][N:4]=[C:3]([CH:2]=[O:1])[CH:8]=1)(=[O:12])[CH3:11]

Participants

4

Reactant 1

HCID 19912998HCID 19912998, compound

Product 1

HCID 19912992HCID 19912992, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

2 g of the thus obtained 2-hydroxymethyl-4-acetylaminopyridine were suspended in 400 ml of dichloromethane, mixed with 6 g of MnO2 and refluxed for 26 hours. The MnO2 was then filtered hot and the dichloromethane solution rotated in to dryness. 1.5 g of 4-acetylaminopyridine-2-aldehyde were obtained.

Workup

  1. temperaturerefluxed for 26 hours
  2. filtrationThe MnO2 was then filtered hot

Sources & evidence

ORD record
ord-5905ec5eaf37463886a8c0c297f7467f
Source dataset
uspto-grants-1991_03
Patent number
US04997835

Reaction notes

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