Hydrazine hydrate (1:1) → 4-Chloro-6-hydrazinylpyrimidine

HRID 358581Notes

Reaction equation

HRID 358581 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]=[CH:4][N:3]=1.O.[NH2:10][NH2:11]>CO>[NH:10]([C:6]1[CH:7]=[C:2]([Cl:1])[N:3]=[CH:4][N:5]=1)[NH2:11]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 709434,6-Dichloropyrimidine

Product 1

HCID 2472224-Chloro-6-hydrazinylpyrimidine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

12 g of 4,6-dichloropyrimidine were dissolved in 100 ml of methanol, mixed dropwise with 12 ml of hydrazine hydrate (80%) and stirred for 1 hour at room temperature. After sucking off the precipitate and washing with H2O, 10 g of 4-hydrazino-6-chloropyrimidine were obtained.

Workup

  1. washwashing with H2O

Sources & evidence

ORD record
ord-de50447722f74a2c9a3e76e5e6f270c5
Source dataset
uspto-grants-1991_03
Patent number
US04997835

Reaction notes

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