Methylhydrazine → HCID 19913001, compound

HRID 358585Notes

Reaction equation

HRID 358585 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.C(N(CC)CC)C.[CH3:16][NH:17][NH2:18]>CO>[Cl:8][C:6]1[N:5]=[CH:4][N:3]=[C:2]([N:17]([CH3:16])[NH2:18])[CH:7]=1

Participants

5

Reactant 3

HCID 6061Methylhydrazine2×HCID 8471Triethylamine2×HCID 709434,6-Dichloropyrimidine

Product 1

HCID 19913001HCID 19913001, compoundYield 112.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2 g of 4,6-dichloropyrimidine were dissolved in 30 ml of methanol, mixed with 1.37 g of triethylamine and 0.63 g of methyl hydrazine and stirred for 2 days at room temperature. 0.1 ml of methyl hydrazine and 0.2 ml of triethylamine were then added and stirred for 4 days at room temperature. After rotating out the solvent, a residue of 2.4 g of crude 6-chloro-4-(1-methyl-hydrazino)-pyrimidine were obtained, which was immediately processed further.

Workup

  1. stirringstirred for 4 days at room temperature

Sources & evidence

ORD record
ord-766908f1a7cc49429fab4f31cd5d1a72
Source dataset
uspto-grants-1991_03
Patent number
US04997835

Reaction notes

Loading…