Hydrochloric Acid → 6-((Phenylsulphonyl)amino)hexanoic acid

HRID 358610Notes

Reaction equation

HRID 358610 reaction equation
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].Cl>[OH-].[Na+]>[C:1]1([S:7]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5646-Aminohexanoic AcidHCID 7369Benzenesulfonyl chloride

Product 1

HCID 30172786-((Phenylsulphonyl)amino)hexanoic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Benzenesulphonyl chloride (10 ml) was added to a stirred solution of 6-aminocaproic acid (8.8 g) in 10% sodium hydroxide solution (50 ml) over 30 minutes. The solution was stirred for 1 hour, acidified with dilute hydrochloric acid and the precipitate was collected by filtration. Recrystallisation from chloroform yielded 6-(benzenesulphonamido)hexanoic acid (10.5 g) as white prisms. m.p. 119°-120° C.

Workup

  1. filtrationthe precipitate was collected by filtration
  2. customRecrystallisation from chloroform

Sources & evidence

ORD record
ord-22843f89e6f0414196a01b312c3696f5
Source dataset
uspto-grants-1991_03
Patent number
US04997847

Reaction notes

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