反应详情

Methyl 7-phthalimidohept-5-ynoate (1.45 g) was dissolved in a mixture of concentrated hydrochloric acid (7.3 ml), acetone (30 ml) and water (14.6 ml) and the resulting solution was heated at reflux for 3.5 hours. The solution was cooled and then poured into water (175 ml). The precipitate was collected by filtration and recrystallised from ethanol-water to give the title compound (1.12 g) m.p. 120°-122° C.

1. temperaturethe resulting solution was heated
2. temperatureat reflux for 3.5 hours
3. temperatureThe solution was cooled
4. filtrationThe precipitate was collected by filtration
5. customrecrystallised from ethanol-water