4-Methoxybenzenesulfonyl chloride → 8-(4-Methoxybenzenesulphonamido)octanoic Acid

HRID 358634Notes

Reaction equation

HRID 358634 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10].[CH3:12][O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1>[OH-].[Na+]>[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([S:20]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9]([OH:11])=[O:10])(=[O:22])=[O:21])=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 660858-Aminooctanoic acid

Product 1

HCID 200669688-(4-Methoxybenzenesulphonamido)octanoic Acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

A solution of 8-aminooctanoic acid in 10% sodium hydroxide solution was treated with 4-methoxybenzenesulphonylchloride in the manner of Example 2 to give the title compound which, on recrystallisation from aqueous 2-propanol, had a melting point of 102°-103° C.

Sources & evidence

ORD record
ord-f5f8b95cdb084ebe9d17e567654ad659
Source dataset
uspto-grants-1991_03
Patent number
US04997847

Reaction notes

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