Hydrochloric Acid → 10-(4-Chlorobenzenesulphonamido)decanoic Acid

HRID 358641Notes

Reaction equation

HRID 358641 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23]C)=[O:22])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([NH:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])(=[O:9])=[O:10])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20066951Methyl 10-(4-chlorobenzenesulphonamido)decanoate

Product 1

HCID 2006697410-(4-Chlorobenzenesulphonamido)decanoic AcidYield 20.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 10-(4-chlorobenzenesulphonamido)decanoate (0.85 g, 0.0023 mol) was treated with 5N sodium hydroxide (15 ml) in ethanol (25 ml) at room temperature for 1 hour. The pH was adjusted to 1 with dilute hydrochloric acid and the precipitated solid was filtered off and recrystallised (isopropanol-ether) to give the title compound (0.17 g, m.p. 192°-4° C.).

Workup

  1. filtrationthe precipitated solid was filtered off
  2. customrecrystallised (isopropanol-ether)

Sources & evidence

ORD record
ord-7a7f03c16cf14c8783f9fc77882bd3df
Source dataset
uspto-grants-1991_03
Patent number
US04997847

Reaction notes

Loading…