Potassium Carbonate → Ethyl-9-(4-chlorobenzenesulphonamido)-2,2-dimethylnonanoate

HRID 358647Notes

Reaction equation

[CH3:1][C:2]([CH3:16])([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]Br)[C:3]([O:5][CH2:6][CH3:7])=[O:4].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH2:27])(=[O:26])=[O:25])=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:6]([O:5][C:3](=[O:4])[C:2]([CH3:16])([CH3:1])[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:27][S:24]([C:21]1[CH:20]=[CH:19][C:18]([Cl:17])=[CH:23][CH:22]=1)(=[O:26])=[O:25])[CH3:7]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 668244-Chlorobenzenesulfonamide

HCID 11369854Nonanoic acid, 9-bromo-2,2-dimethyl-, ethyl ester

Product 1

HCID 20066938Ethyl-9-(4-chlorobenzenesulphonamido)-2,2-dimethylnonanoateYield 53%

Procedure

Ethyl 2,2-dimethyl-9-bromononanoate (2.0 g, 0.007 mol) was treated with 4-chlorobenzenesulphonamide (3.44 g, 0.018 mol) and potassium carbonate (6.2 g, 0.045 mol) by the method described in Example 5(ii) to give the title compound (1.5 g) as an oil.

Sources & evidence

ORD record: ord-ecf46ced0e594d84b13e68c06a09497e
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04997847

Reaction notes

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