Potassium Carbonate → Ethyl-7-(4-chlorophenylsulphonamido)-2,2-dimethylheptanoate

HRID 358649Notizen

Reaktionsgleichung

[CH2:1]([O:3][C:4](=[O:14])[C:5]([CH3:13])([CH3:12])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]Br)[CH3:2].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH2:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1.C(=O)([O-])[O-].[K+].[K+]>>[CH2:1]([O:3][C:4](=[O:14])[C:5]([CH3:13])([CH3:12])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:25][S:22]([C:19]1[CH:18]=[CH:17][C:16]([Cl:15])=[CH:21][CH:20]=1)(=[O:24])=[O:23])[CH3:2]

Komponenten

Edukt 3

HCID 11430Potassium Carbonate

HCID 668244-Chlorobenzenesulfonamide

HCID 11265571Ethyl 7-bromo-2,2-dimethylheptanoate

Produkt 1

HCID 20066981Ethyl-7-(4-chlorophenylsulphonamido)-2,2-dimethylheptanoateAusbeute 13,3 %

Versuchsvorschrift

Ethyl-2,2-dimethyl-7-bromoheptanoate (7.0 g, 0.026 mol) was treated with 4-chlorobenzenesulphonamide (9.9 g, 0.052 mol) and potassium carbonate (21.5 g, 0.016 mol) by the method described in Example 5(ii) to give the title compound (1.3 g) as an oil.

Quellen und Nachweise

ORD-Eintrag: ord-5da6c82ea9584078a688cc061d641b84
Quelldatensatz: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04997847

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