Piperidine → HCID 23128128, compound

HRID 358686Notes

Reaction equation

HRID 358686 reaction equation
C([O:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][C:15]([CH3:21])=[CH:16][CH:17]=2)[N:12]([CH3:22])[CH:11]=1)(=O)C1C=CC=CC=1.N1CCCCC1>ClCCl>[OH:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][C:15]([CH3:21])=[CH:16][CH:17]=2)[N:12]([CH3:22])[CH:11]=1

Participants

4

Reactant 2

HCID 8082Piperidine2×HCID 23128143HCID 23128143, compound

Product 1

HCID 23128128HCID 23128128, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 1,7-dimethyl-4-oxo-1,4-dihydroquinol-3-yl benzoate (1.45 g), piperidine (0.49 ml) and dichloromethane (14 ml) was stirred at ambient temperature under nitrogen for 3 days. Further piperidine (0.13 ml) was added and the mixture stirred overnight. The solvent was removed by distillation and the residue triturated with diethyl ether (20 ml) to give the novel compound 3-hydroxy-1,7- dimethyl-4quinolone, m.p. 268°.

Workup

  1. stirringthe mixture stirred overnight
  2. customThe solvent was removed by distillation
  3. customthe residue triturated with diethyl ether (20 ml)

Sources & evidence

ORD record
ord-5d80999db59d41babd484622979b6b54
Source dataset
uspto-grants-1991_03
Patent number
US04997840

Reaction notes

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