反应详情

Dimethyl sulphate (26.1ml) was added to a stirred suspension of 4-hydroxy-7-trifluoromethylquinol-3-yl methanesulphonate (7.19 g) and potassium carbonate (75.5 g) in dry 2-butanone (350 ml) and the resultant mixture was heated under reflux for 5 hours. The solvent was removed by distillation and the resultant residue was extracted with dichloromethane (600 ml then 400 ml). The combined extracts were dried over magnesium sulphate and the solvent was removed by distillation. The residue was purified by flash chromatography on a silica gel column eluted with dichloromethane:methanol (75:1) followed by flash chromatography on a silica gel column eluted with ethyl acetate and crystallisation from industrial methylated spirit (150 ml) to give the novel compound 1-methyl-4-oxo-7-trifluoromethyl-1,4-dihydroquinol-3-yl methanesulphonate, m.p. 218°.

1. temperatureunder reflux for 5 hours
2. customThe solvent was removed by distillation
3. extractionthe resultant residue was extracted with dichloromethane (600 ml
4. dry with materialThe combined extracts were dried over magnesium sulphate
5. customthe solvent was removed by distillation
6. customThe residue was purified by flash chromatography on a silica gel column
7. washeluted with dichloromethane:methanol (75:1)
8. washeluted with ethyl acetate and crystallisation from industrial methylated spirit (150 ml)