Piperidine → HCID 23128115, compound

HRID 358707Notes

Reaction equation

HRID 358707 reaction equation
C([O:9][C:10]1[C:19](=[O:20])[C:18]2[C:13](=[CH:14][C:15]([Cl:21])=[CH:16][CH:17]=2)[N:12]([CH3:22])[CH:11]=1)(=O)C1C=CC=CC=1.N1CCCCC1>ClCCl>[Cl:21][C:15]1[CH:14]=[C:13]2[C:18]([C:19](=[O:20])[C:10]([OH:9])=[CH:11][N:12]2[CH3:22])=[CH:17][CH:16]=1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 23128163HCID 23128163, compound

Product 1

HCID 23128115HCID 23128115, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 7-chloro-1-methyl-4-oxo-1,4-dihydro-quinol-3-yl benzoate (3.45 g), piperidine (1.2 ml) and dichloromethane (100 ml) was stirred at ambient temperature for 2.5 days. The solvent was removed by distillation and the residue triturated with diethyl ether (100 ml) to give the novel compound 7-chloro-3-hydroxy-1-methyl-4-quinolone, m.p. 225°-228°.

Workup

  1. customThe solvent was removed by distillation
  2. customthe residue triturated with diethyl ether (100 ml)

Sources & evidence

ORD record
ord-7825fd6dc0214d2e9417d3ca59912a7a
Source dataset
uspto-grants-1991_03
Patent number
US04997840

Reaction notes

Loading…