2-Ethylhexanoyl chloride → HCID 20066911, compound

HRID 358742Notes

Reaction equation

[NH2:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH2:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=2[O:22][CH3:23])=[CH:4][CH:3]=1.[CH2:24]([CH:26]([CH2:30][CH2:31][CH2:32][CH3:33])[C:27](Cl)=[O:28])[CH3:25]>>[CH2:24]([CH:26]([CH2:30][CH2:31][CH2:32][CH3:33])[C:27]([NH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[N:7][N:8]2[CH2:11][C:12]2[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][C:13]=2[O:22][CH3:23])=[CH:4][CH:3]=1)=[O:28])[CH3:25]

Participants

Reactant 2

HCID 791032-Ethylhexanoyl chloride

HCID 14708764HCID 14708764, compound

Product 1

HCID 20066911HCID 20066911, compoundYield 68%

Procedure

Using an analogous procedure to that described in Example 1, but starting from methyl 4-(6-aminoindazol-1-ylmethyl)-3-methoxybenzoate and 2-ethylhexanoyl chloride, there was obtained methyl 4-[6-(2-ethylhexanamido)indazol-1-ylmethyl]-3-methoxybenzoate in 68% yield as a white solid, m.p. 135.5°-136.5° C.; microanalysis, found: C, 68.37; H, 7.10; N, 9.43%; C25H31,N3O4 requires: C, 68.64; H, 7.14; N, 9.60%.

Sources & evidence

ORD record: ord-4995eb7f1a4b4f26b84b7e0b54f00533
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04997844

Reaction notes

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