Methyl 4-(bromomethyl)-3-methoxybenzoate → HCID 19744336, compound

HRID 358745Notes

Reaction equation

HRID 358745 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[NH:7][CH:6]=[CH:5]2.Br[CH2:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][C:17]=1[O:26][CH3:27]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[N:7]([CH2:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]([O:22][CH3:23])=[O:21])=[CH:18][C:17]=1[O:26][CH3:27])[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 2759828Methyl 4-(bromomethyl)-3-methoxybenzoateHCID 197443315-bromo-6-nitro-1H-indole

Product 1

HCID 19744336HCID 19744336, compoundYield 65%

Procedure

5-Bromo-6-nitroindole was reacted with methyl 4-bromomethyl-3-methoxybenzoate using the procedure described in part (a) of Example 1 to give methyl 4-(5-bromo-6-nitroindol-1-ylmethyl)-3-methoxybenzoate (HH) in 65% yield and as a bright yellow solid; partial NMR: 3.89 (s,3H,OCH3), 3.94 (s,3H,OCH3), 5.35 (s,2H,NCH2), 6.53 (dd,1H,H3 -indole), 7.38 (d,1H,H2 -indole), 7.89 (s,1H,H4 -indole), 8.03 (br s,1H,H7 -indole).

Sources & evidence

ORD record
ord-8db670433ffb46d78ad17f9eed893870
Source dataset
uspto-grants-1991_03
Patent number
US04997844

Reaction notes

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