反应详情

315 g (1 mol) of N-(4-phenoxy-2,6-diisopropylphenyl)thiourea are suspended in 800 ml of o-xylene, and the suspension is heated for 5 hours to reflux temperature, whereupon the temperature of the reaction mixture rises to ca. 150° C. The reaction mixture is then cooled, the solvent is removed by vacuum distillation, and the crude product is purified by distillation under a high vacuum, giving 278 g (93% of theory) of 4-phenoxy-2,6-diisopropylphenylisothiocyanate as a pale yellow oil with a boiling point of 130°-140° C./0.05 mbar.

1. temperaturethe suspension is heated for 5 hours
2. temperatureto reflux temperature
3. customrises to ca. 150° C
4. temperatureThe reaction mixture is then cooled
5. customthe solvent is removed by vacuum distillation
6. distillationthe crude product is purified by distillation under a high vacuum