反应详情

温度

85 °C

To a one liter, 3-necked round bottom flask which was equipped with a mechanical stirrer, thermometer, and reflux condenser were added absolute ethanol (180 ml.) and pentylamine (100.0 g., 1.15 mol). The amine solution was cooled in an ice bath while glacial acetic acid (68.9 g., 1.15 mol) was slowly added. Amidinothiourea (90.37 g., 0.76 mol) was added and then the mixture was heated to reflux (85° C.). After 24 hours at reflux, HPLC analysis of the reaction solution indicated that title product (72.6 area %) had formed and that residual amidinothiourea (8.5 area %) remained.

1. customTo a one liter, 3-necked round bottom flask which was equipped with a mechanical stirrer
2. temperaturethermometer, and reflux condenser
3. additionwas slowly added
4. temperaturethe mixture was heated
5. temperatureAfter 24 hours at reflux