反应详情

1.1 g (0.02 mole) of hydrazine hydrate was added to a suspension of 2.15 g (0.007 mole) of N-(3-methoxy-2,4,5-trifluorophenyl)phthalimide (XXXVI) [prepared as described in Step (F3) above] in 30 ml of ethanol, and the mixture was heated under reflux with stirring for 2 hours. The reaction mixture was cooled to room temperature and then filtered. The filtrate was concentrated by evaporation under reduced pressure, and the residue was dissolved in toluene. The resulting solution was washed with water and dried, and the solvent was then removed by evaporation under reduced pressure to afford 1.06 g of 3-methoxy-2,4,5-trifluoroaniline (XXIII) as pale brown needles.

1. temperaturethe mixture was heated
2. temperatureunder reflux
3. filtrationfiltered
4. concentrationThe filtrate was concentrated by evaporation under reduced pressure
5. dissolutionthe residue was dissolved in toluene
6. washThe resulting solution was washed with water
7. customdried
8. customthe solvent was then removed by evaporation under reduced pressure