Ammonia → 2-Amino-3,5,6-trifluoro-4-methoxybenzonitrile

HRID 358873Notes

Reaction equation

HRID 358873 reaction equation
[NH3:1].[CH3:2][O:3][C:4]1[C:11]([F:12])=[C:10](F)[C:7]([C:8]#[N:9])=[C:6]([F:14])[C:5]=1[F:15]>>[NH2:1][C:10]1[C:11]([F:12])=[C:4]([O:3][CH3:2])[C:5]([F:15])=[C:6]([F:14])[C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 144572672,3,5,6-Tetrafluoro-4-methoxybenzonitrile

Product 1

HCID 144572682-Amino-3,5,6-trifluoro-4-methoxybenzonitrile

Procedure

150 ml of liquid ammonia and 100.0 g (0.49 mole) of 4-methoxy-2,3,5,6-tetrafluorobenzonitrile (XIX) [prepared as described in Step (E1) above] were placed in an autoclave, and the mixture was allowed to stand at room temperature overnight. The ammonia was then evaporated off, and the solid obtained was washed with water to afford 84.4 g of 2-amino-4-methoxy-3,5,6-trifluorobenzonitrile (XX) as a colorless powder.

Workup

  1. customThe ammonia was then evaporated off
  2. customthe solid obtained
  3. washwas washed with water

Sources & evidence

ORD record
ord-e7b115f17bd44a26849763d47a974775
Source dataset
uspto-grants-1991_03
Patent number
US04997943

Reaction notes

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