Ammonia → 2-Amino-3,5,6-trifluoro-4-methoxybenzonitrile

Participants

Reaction Steps

150 ml of liquid ammonia and 100.0 g (0.49 mole) of 4-methoxy-2,3,5,6-tetrafluorobenzonitrile (XIX) [prepared as described in Step (E1) above] were placed in an autoclave, and the mixture was allowed to stand at room temperature overnight. The ammonia was then evaporated off, and the solid obtained was washed with water to afford 84.4 g of 2-amino-4-methoxy-3,5,6-trifluorobenzonitrile (XX) as a colorless powder.

Provenance & Evidence