反应详情

温度

95 °C

Thionyl chloride (0.20 ml, 0.027 mol) and dimethylformamide (0.15 ml, 0.022 mol) were added to a solution of 5 (0.624 g, 0.020 mol) in toluene (2 ml) at 50° C. The mixture was stirred and heated to 95° C. over a period of 15 min. and maintained at that temperature for another hour. The pale yellow solution was washed with water, dried over magnesium sulfate, treated with activated carbon, filtered, and evaporated to give a cream-colored solid (0.600 g, 95% yield). The melting point of the material so obtained was 194-195° C. (195-196° C. after recrystallization from acetic acid).

1. temperaturemaintained at that temperature for another hour
2. washThe pale yellow solution was washed with water
3. dry with materialdried over magnesium sulfate
4. additiontreated with activated carbon
5. filtrationfiltered
6. customevaporated