Ethyl bromoacetate → HCID 14536939, compound

HRID 358949Notes

Reaction equation

HRID 358949 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].C(=O)([O-])[O-].[Cs+].[Cs+].[O:13]=[C:14]([C:23]1[CH:28]=[CH:27][C:26]([OH:29])=[CH:25][CH:24]=1)[CH2:15][NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19].Br[CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33]>CS(C)=O>[O:13]=[C:14]([C:23]1[CH:24]=[CH:25][C:26]([O:29][CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])=[CH:27][CH:28]=1)[CH2:15][NH:16][C:17](=[O:22])[C:18]([F:20])([F:21])[F:19]

Participants

6

Reactant 4

HCID 7748Ethyl bromoacetateHCID 10340Sodium CarbonateHCID 10796Cesium carbonateHCID 14536938HCID 14536938, compound

Product 1

HCID 14536939HCID 14536939, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

1.06 g of sodium carbonate or 3.26 g of cesium carbonate were added to a stirred solution of 2.47 g of 4-(1-oxo-2-trifluoroacetamidoethyl)-phenol (1e) in 5 ml of dimethyl sulfoxide at room temperature and, after 30 minutes, 1.83 g of ethyl bromoacetate were introduced. Precipitating crystalline solid gradually made the mixture more viscous. After about 2 hours, the mixture solidified to a thick, unstirrable crystal slurry.

Sources & evidence

ORD record
ord-71807caa7de94724a3ec176ad019e1d5
Source dataset
uspto-grants-1991_03
Patent number
US04999345

Reaction notes

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