4-(Pyrrolidin-1-yl)carbonyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine → 4-(Pyrrolidin-1-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine

HRID 358969Notes

Reaction equation

HRID 358969 reaction equation
[N:1]1([C:6]([CH:8]2[C:13]3[N:14]=[CH:15][NH:16][C:12]=3[CH2:11][CH2:10][NH:9]2)=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCOCC1>[N:1]1([CH2:6][CH:8]2[C:13]3[N:14]=[CH:15][NH:16][C:12]=3[CH2:11][CH2:10][NH:9]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 200656934-(Pyrrolidin-1-yl)carbonyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridineHCID 21226445Aluminium lithium hydride

Product 1

HCID 200656974-(Pyrrolidin-1-yl)methyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.63 g (16.48 mmoles) of 4-(pyrrolidin-1-yl)carbonyl-4,5,6,7-tetrahydroimidazo[4,5-c]pyridine were added portionwise, at room temperature, under nitrogen atmosphere, to a slurry of 1.00 g (26.32 mmoles) of lithium aluminium hydride in 180 ml of dry dioxane.

Sources & evidence

ORD record
ord-3f8afb5197e244b2905297b9140d96b2
Source dataset
uspto-grants-1991_03
Patent number
US04999359

Reaction notes

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