反应详情

A mixture of 4.9 g of 1-phenyl-3-(1-piperazinyl)-1H-indazole, 5.1 g of nitrourea, and 80 ml of dimethylformamide was heated on a steam bath for 15 minutes. The reaction mixture was then poured into water and the resulting precipitate was recrystallized from ethyl acetate (2×) to yield 3.1 g (57%) of 4-(1-phenyl-1H-indazol-3-yl)-1-piperazine carboxamide, m.p. 151°-153°.

1. temperaturewas heated on a steam bath for 15 minutes
2. customthe resulting precipitate was recrystallized from ethyl acetate (2×)