Ethyl Acetate → ethyl 1-methyl-1H-benzofuro[2,3-g]indole-2-carboxylate

HRID 359238Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]3[O:12][C:11]4[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=4[C:8]3=2)[CH:3]=[C:2]1[C:17]([O:19][CH2:20][CH3:21])=[O:18].[CH3:22]COC(C)=O>>[CH3:22][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]3[O:12][C:11]4[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=4[C:8]3=2)[CH:3]=[C:2]1[C:17]([O:19][CH2:20][CH3:21])=[O:18]

Participants

Reactant 2

HCID 8857Ethyl Acetate

HCID 13438846ethyl 1H-benzofuro[2,3-g]indole-2-carboxylate

Product 1

HCID 15170283ethyl 1-methyl-1H-benzofuro[2,3-g]indole-2-carboxylateYield 86.3%

Procedure

Using the procedure outlined in Example 34A, ethyl 1H-benzofuro[2,3-g]indole-2-carboxylate (H. G. Pars Pharmaceutical Laboratories, Inc.) gave a 86.3% yield of ethyl 1-methyl-1H-benzofuro[2,3-g]indole-2-carboxylate, mp 114°-116°, (EtOAc), (C,H,N).

Sources & evidence

ORD record: ord-bbe1ef3df1f54ee096802a4e9cfefb57
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04999369

Reaction notes

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