N-Isopropylaniline → Ethyl 2-[(1-methylethyl)phenylamino]-4-(trifluoromethyl)-5-oxazolecarboxylate

HRID 359270노트

반응식

HRID 359270 반응식
[CH:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)([CH3:3])[CH3:2].Cl[C:12]1[O:13][C:14]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:15]([C:17]([F:20])([F:19])[F:18])[N:16]=1>C(OCC)C>[CH3:2][CH:1]([N:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:12]1[O:13][C:14]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[C:15]([C:17]([F:19])([F:18])[F:20])[N:16]=1)[CH3:3]

참가 물질

4

반응물 2

HCID 13032N-IsopropylanilineHCID 12785855Ethyl 2-chloro-4-(trifluoromethyl)oxazole-5-carboxylate

생성물 1

HCID 54213079Ethyl 2-[(1-methylethyl)phenylamino]-4-(trifluoromethyl)-5-oxazolecarboxylate수율 21.5%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

By the procedure of Example 15, 2.59 g (0.019 mol) of N-isopropyl aniline was reacted neat with 2.32 g (0.0095 mol) of ethyl 2-chloro-4-trifluromethyl-5-oxazolecarboxylate at 140°-150° C. for 4 hours. The product mixture was slurried in ethyl ether, washed with 25% sulfuric acid and water, dried and concentrated. The residue was distilled and the distillate was recrystallized from methylcyclohexane to yield 0.7 g of a white-powder product (m.p.=66°-68° C.) identified in Table 1.

후처리

  1. washwashed with 25% sulfuric acid and water
  2. customdried
  3. concentrationconcentrated
  4. distillationThe residue was distilled
  5. customthe distillate was recrystallized from methylcyclohexane

출처 및 근거

ORD 기록
ord-13169db03b204bc188961253cda4b076
출처 데이터셋
uspto-grants-1991_03
특허 번호
US05000775

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