Thionyl Chloride → HCID 20064749, compound

HRID 359279Notes

Reaction equation

HRID 359279 reaction equation
[C:1]([NH:5][C:6]1[O:7][C:8]([C:15]([OH:17])=O)=[C:9]([C:11]([F:14])([F:13])[F:12])[N:10]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:20])=O>CN(C)C=O>[CH3:2][C:1]([NH:5][C:6]1[O:7][C:8]([C:15]([Cl:20])=[O:17])=[C:9]([C:11]([F:14])([F:13])[F:12])[N:10]=1)([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 15812073HCID 15812073, compound

Product 1

HCID 20064749HCID 20064749, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By the procedure of Example 27, 17 g (64.5 mmol) of 2-(tert-butylamino)-4-trifluoromethyl-5-oxazolecarboxylic acid, 67 ml thionyl chloride and 4 of drops dimethylformamide were reacted together. The product was separated and then distilled to yield 17.2 g of a yellow solid product (m.p.=52°-60° C.; b.p. 70° C. @ 0.25 mm Hg) identified in Table I.

Workup

  1. customThe product was separated
  2. distillationdistilled

Sources & evidence

ORD record
ord-3f5b19ad54034452bb000a87a1633a77
Source dataset
uspto-grants-1991_03
Patent number
US05000775

Reaction notes

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