Tert-Butylamine → HCID 20064740, compound

HRID 359287Notes

Reaction equation

HRID 359287 reaction equation
[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].Cl[C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:15])([F:14])[F:13])[N:11]=1>C(#N)C>[CH3:2][C:1]([NH:5][C:7]1[S:8][C:9]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[C:10]([C:12]([F:14])([F:13])[F:15])[N:11]=1)([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 6385Tert-ButylamineHCID 91715Flurazole

Product 1

HCID 20064740HCID 20064740, compoundYield 42.6%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

By the procedure of Example 39, a stirred mixture of 15 ml of acetonitrile, 2.72 g (38 mmol) of tert-butylamine, and 6 g (19 mmol) of benzyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506), was heated at reflux for 66 hours. The product was separated and then recrystallized from hexane to yield 2.90 g of an off-white powder product (m.p.=79°-81° C.) identified in Table I.

Workup

  1. customprepared
  2. temperature4,199,506), was heated
  3. temperatureat reflux for 66 hours
  4. customThe product was separated
  5. customrecrystallized from hexane

Sources & evidence

ORD record
ord-3b354d60647e49aba91fd559100fef17
Source dataset
uspto-grants-1991_03
Patent number
US05000775

Reaction notes

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