反应详情

By the procedure of Example 4, 10 g (78 mmol) of cyclopentyl urea was reacted with 10.7 g (65 mmol) of ethyl 2-chloroacetoacetate at 140°-150° C. for 4 hours. The product was separated, then purified by Kugelrohr distillation (135° C. @ 0.5 mm Hg) and then recrystallized from hexane to yield 2.54 g of a light yellow solid product (m.p.=50°-52° C.) identified in Table I.

1. customThe product was separated
2. distillationpurified by Kugelrohr distillation (135° C. @ 0.5 mm Hg)
3. customrecrystallized from hexane