反应详情

A partial solution of ?? g of α-chloro-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]benzeneacetamide in 1 ml of methanol is treated with 0.5 ml of dimethylamine and 1 ml of 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone and stirring continued for 20 hours. The methanol is evaporated and the residue diluted with water. The resulting solid is washed with water, dissolved in ethyl acetate and the organic layer washed with saturated NaHCO3, brine and dried with Na2SO4. The mixture is filtered and the filtrate evaporated in vacuo to give a residue which is stirred with ethyl acetate-hexane to give 0.15 g of a beige solid. MS(CI): 465 (M+H).

1. customThe methanol is evaporated
2. additionthe residue diluted with water
3. washThe resulting solid is washed with water
4. dissolutiondissolved in ethyl acetate
5. washthe organic layer washed with saturated NaHCO3, brine
6. dry with materialdried with Na2SO4
7. filtrationThe mixture is filtered
8. customthe filtrate evaporated in vacuo
9. customto give a residue which