Hydrochloric Acid → HCID 19095582, compound

HRID 359411Notes

Reaction equation

HRID 359411 reaction equation
[ClH:1].[CH3:2][C:3]1[CH:4]=[C:5]([C:9]2(O)[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:10]2)[CH:6]=[CH:7][CH:8]=1.Cl>>[ClH:1].[CH3:2][C:3]1[CH:4]=[C:5]([C:9]2[CH2:13][CH2:12][N:11]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:10]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19095617HCID 19095617, compound

Product 1

HCID 19095582HCID 19095582, compoundYield 100%

Procedure

A mixture of 8 parts of 3-(3-methylphenyl)-1-(phenylmethyl)-3-pyrrolidinol hydrochloride and 150 parts of a hydrochloric acid solution 6 N was stirred and refluxed for 3 hours. After cooling, the reaction mixture was evaporated, yielding 7.4 parts (100%) of 2,3-dihydro-4-(3-methylphenyl)-1-(phenylmethyl)-1H-pyrrole hydrochloride as a residue (intermediate 47).

Workup

  1. temperaturerefluxed for 3 hours
  2. temperatureAfter cooling
  3. customthe reaction mixture was evaporated

Sources & evidence

ORD record
ord-25ea28e526804cf9b582c5b128e11f64
Source dataset
uspto-grants-1991_03
Patent number
US05001125

Reaction notes

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