反应详情

A mixture of 3 parts of 3-chloro-6-(1-piperazinyl)pyridazine. 2 parts of benzeneacetylaldehyde, 1 part of a solution of thiophene in methanol 4% and 200 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of platinum-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated. The residue was crystallized from 2-propanol. The product was filtered off and dried, yielding 1.5 parts (33%) of 3-chloro-6-[4-(2-phenylethyl)-1-piperazinyl]pyridazine; mp. 140.0° C. (compound 231).

1. filtrationthe catalyst was filtered off
2. customthe filtrate was evaporated
3. customThe residue was crystallized from 2-propanol
4. filtrationThe product was filtered off
5. customdried