反应详情

温度

150 °C

A mixture of 1.9 parts of phenol, 2.9 parts of 3-chloro-6-[4-(3-methylpheyl)-1-piperazinyl]pyridazine and 2.76 parts of potassium carbonate was stirred and heated for 7 hours in an oil bath at 150° C. After cooling, water was added. The product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The residue was crystallized from a mixture of 2-propanol and 2,2'-oxybispropane. The product was filtered off and dried, yielding 2 parts (60%) of 3-[4-(3-methylphenyl)-1-piperazinyl]-6-phenoxypyridazine: mp. 123.4° C. (compound 264).

1. temperatureAfter cooling
2. extractionThe product was extracted with trichloromethane
3. customThe extract was dried
4. filtrationfiltered
5. customevaporated
6. customThe residue was crystallized from a mixture of 2-propanol and 2,2'-oxybispropane
7. filtrationThe product was filtered off
8. customdried