反应详情

A solution of 1-[(methylsulphonyl)methyl]-4-nitrobenzene (4 g) in ethyl acetate (300 ml) containing a catalytic amount of palladium on carbon (10%, prehydrogenated, 0.5 g) was hydrogenated at room temperature and pressure until hydrogen uptake ceased (1400 ml, 1 h). The catalyst was filtered off and the filter cake washed with warm ethanol (2×80 ml). The filtrates were combined and concentrated under vacuum to afford the title compound (1.9 g) as a pale yellow crystalline solid, m.p. 167°-168° C.

1. customwas hydrogenated at room temperature
2. custom(1400 ml, 1 h)
3. filtrationThe catalyst was filtered off
4. washthe filter cake washed with warm ethanol (2×80 ml)
5. concentrationconcentrated under vacuum