Cinalukast → HCID 86744665, compound

HRID 359493Notes

Reaction equation

HRID 359493 reaction equation
[OH:1][C:2]([NH:5][CH3:6])([OH:4])[OH:3].[CH:7]1([C:11]2[N:12]=[C:13](/[CH:16]=[CH:17]/[C:18]3[CH:19]=[C:20]([NH:24][C:25](=[O:35])[CH2:26][C:27]([CH2:33][CH3:34])([CH2:31][CH3:32])[C:28]([OH:30])=[O:29])[CH:21]=[CH:22][CH:23]=3)[S:14][CH:15]=2)[CH2:10][CH2:9][CH2:8]1>C(O)C>[OH:1][C:2]([NH:5][CH3:6])([OH:4])[OH:3].[CH:7]1([C:11]2[N:12]=[C:13](/[CH:16]=[CH:17]/[C:18]3[CH:19]=[C:20]([NH:24][C:25](=[O:35])[CH2:26][C:27]([CH2:33][CH3:34])([CH2:31][CH3:32])[C:28]([OH:30])=[O:29])[CH:21]=[CH:22][CH:23]=3)[S:14][CH:15]=2)[CH2:10][CH2:9][CH2:8]1

Participants

4

Reactant 2

HCID 6436135CinalukastHCID 9877341Tri-hydroxymethylaminomethane

Product 1

HCID 86744665HCID 86744665, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Tri-hydroxymethylaminomethane (121.4 mg) and 412.5 mg of (E)-4-[[3-[2-(4-cyclobutyl-2-thiazolyl)-ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid were dissolved in 10 ml of ethanol. This solution was then condensed by rotary evaporation to yield (E)-4-[[3-[2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid tri-hydroxymethylaminomethane salt as a free flowing solid after trituration with cold acetonitrile, m.p. 80°-87° C.

Workup

  1. customcondensed
  2. customby rotary evaporation

Sources & evidence

ORD record
ord-a5c6fa487af54ef3bfb476c7af93704a
Source dataset
uspto-grants-1991_03
Patent number
US05001140

Reaction notes

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