Cinalukast → HCID 86744665, compound

Participants

Reaction Steps

Tri-hydroxymethylaminomethane (121.4 mg) and 412.5 mg of (E)-4-[[3-[2-(4-cyclobutyl-2-thiazolyl)-ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid were dissolved in 10 ml of ethanol. This solution was then condensed by rotary evaporation to yield (E)-4-[[3-[2-(4-cyclobutyl-2-thiazolyl)ethenyl]phenyl]amino]-2,2-diethyl-4-oxobutanoic acid tri-hydroxymethylaminomethane salt as a free flowing solid after trituration with cold acetonitrile, m.p. 80°-87° C.

Provenance & Evidence