反应详情

0.2 g of sodium hydride 60% in oil was added to a solution of 1.3 g of 1-(2-chloro-5-pyridylmethyl)-2-nitromethyleneimidazolidine in 15 ml of dry dimethylformamide, and the mixture was stirred at room temperature until the generation of hydrogen gas ceased. 0.9 g of 4-chlorobenzenesulfenylchloride was then drop into the solution at 0° C. with stirring. After stirring for 1 hour at room temperature, the reaction mixture was poured into ice water. The precipitated crystal was filtered and recrystalized from ethyl acetate to give 1-(2-chloro-5-pyridylmethyl)-2-{(4chlorophenylthio)nitromethylene}imidazolidine. The yield was 1.3 g.

1. customwas then drop into the solution at 0° C.
2. stirringAfter stirring for 1 hour at room temperature
3. filtrationThe precipitated crystal was filtered
4. customrecrystalized from ethyl acetate