HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → (E)-3-(7-(4-fluorophenyl)-9,9-dimethyl-1,4-dioxaspiro-{4,5}dec-7-en-8-yl)propenal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | N-cyclohexylethanimine | HCID 10964544 | — |
| Reactant | 7-(4-Fluorophenyl)-9,9-dimethyl-1,4-dioxaspiro{4,5}-dec-7-en-8-carboxaldehyde | HCID 15056962 | — |
| Product | (E)-3-(7-(4-fluorophenyl)-9,9-dimethyl-1,4-dioxaspiro-{4,5}dec-7-en-8-yl)propenal | HCID 15056963 | — |
Reaction Steps
In a manner similar to Scheme I, 26 (2.08 g, 7.17 mmol) was treated with the LDA-derived anion of ethylidenecyclohexylamine (1.36 g, 10.8 mmol) in anhydrous THF at 0°-5° C. and after workup and purification by SiO2 using 6:1 hexanes:EtOAc as eluent provided 1.25 g of orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05001144 |
| Source dataset | uspto-grants-1991_03 |
| ORD ID | ord-c6fc965f0a2541b78c535107f72e09b0 |
| Source note | uspto-grants-1991_03 |