反应详情

In a manner similar to Scheme I, 33 (2.27 g, 6.65 mmol) was treated with the LDA derived anion of methyl acetoacetate (7.98 mmol) followed by triethylborane, methanol, and NaBH4 . Workup and purification by HPLC. using 1% Et3N in EtOAc as eluent provided the oily product.

1. customWorkup and purification by HPLC
2. customprovided the oily product