1,2-Dichloroethane → cis-2-(4-methoxyphenyl)-2,3-dihydro-3-hydroxy-5-(2-chloroethyl)-1,5-benzothiazepin-4(5H)-one

HRID 359582Notes

Reaction equation

HRID 359582 reaction equation
[H-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([C@H:11]2[C@@H:17]([OH:18])[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[S:12]2)=[CH:7][CH:6]=1.[H][H].[Cl:26][CH2:27][CH2:28]Cl>CCOCC.O.CS(C)=O>[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([C@H:11]2[C@@H:17]([OH:18])[C:16](=[O:19])[N:15]([CH2:28][CH2:27][Cl:26])[C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[S:12]2)=[CH:9][CH:10]=1

Participants

8

Reactant 4

HCID 111,2-DichloroethaneHCID 24758Sodium hydrideHCID 27336733-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one, (2S,3S)-HCID 178418361HCID 178418361, compound

Product 1

HCID 86744667cis-2-(4-methoxyphenyl)-2,3-dihydro-3-hydroxy-5-(2-chloroethyl)-1,5-benzothiazepin-4(5H)-oneYield 24.9%

Reagents, catalysts & solvents 3

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

Under a nitrogen blanket, 7.47 g of 80 percent sodium hydride (Aldrich; 0.249 mol) and 600 mL of anhydrous dimethyl sulfoxide (DMSO) were added to a 2-L round bottom flask, which had been fitted with a reflux condenser, nitrogen adapter and magnetic stirrer. The resulting solution was stirred for 45 minutes, and then 50.0 g of dl-cis-2-(4-methoxyphenyl)-2,3-dihydro-3-hydroxy -1,5-benzothiazepin-4(5H)-one (0.166 mol) was added in two portions over a ten minute period. A fairly vigorous evolution of hydrogen gas ensued. The reaction mixture was stirred for 50 minutes, and then 40 mL of anhydrous 1,2-dichloroethane (Aldrich; 0.508 mol) was added all at once. The reaction mixture was stirred for 40 hours, whereupon 750 mL of cold water was added thereto. Ether was used to extract the desired alkylated product, which was dried over drying agent. This product was taken up with dichloromethane, and it was dried further. The product was chromatographed on 70-230 mesh silica gel column, with a 2:1 hexane to ethyl acetate eluent. Concentration under high vacuum yielded 15.05 g of dl-cis-2-(4-methoxyphenyl) -2,3-dihydro-3-hydroxy-5-(2-chloroethyl)-1,5-benzothiazepin -4(5H)-one (24.9 percent of theory).

Workup

  1. customwhich had been fitted with a reflux condenser, nitrogen adapter and magnetic stirrer
  2. stirringThe reaction mixture was stirred for 50 minutes
  3. additionwas added
  4. extractionto extract the
  5. customwas dried
  6. customover drying agent
  7. customwas dried further
  8. customThe product was chromatographed on 70-230 mesh silica gel column, with a 2:1 hexane to ethyl acetate eluent
  9. concentrationConcentration under high vacuum

Sources & evidence

ORD record
ord-f19c951008474e20acb646fc7558eccd
Source dataset
uspto-grants-1991_03
Patent number
US05001236

Reaction notes

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