Heptafluorobutanol → HCID 14330157, compound

HRID 359606Notes

Reaction equation

HRID 359606 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Cl)([O-:3])=[O:2].[F:12][C:13]([F:23])([C:16]([F:22])([F:21])[C:17]([F:20])([F:19])[F:18])[CH2:14][OH:15].[OH-].[K+]>CN(C)C=O>[F:12][C:13]([F:23])([C:16]([F:21])([F:22])[C:17]([F:18])([F:19])[F:20])[CH2:14][O:15][CH2:7][C:6]1[CH:9]=[CH:10][CH:11]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

Participants

5

Reactant 3

HCID 9776HeptafluorobutanolHCID 12078alpha-Chloro-m-nitrotolueneHCID 14797Potassium Hydroxide

Product 1

HCID 14330157HCID 14330157, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

100.0 g (0.58 mol) of 3-nitrobenzyl chloride and 128.3 g (0.62 mol, 1.05 equivalents) of 2,2,3,3,4,4,4-heptafluorobutanol(purity: 96%) were dissolved in 300 ml of dimethylformamide. To the resultant mixture 49.0 g (0.88 mol, 1.5 equivalents) of KOH pellets were added while the mixture was being cooled in a water bath. The reaction temperature is elevated to 43° C. and thereafter gradually restored to room temperature, and the reaction was completed after 30 minutes.

Workup

  1. temperaturewas being cooled in a water bath
  2. customis elevated to 43° C.
  3. customgradually restored to room temperature

Sources & evidence

ORD record
ord-69fd71bbc8ab43219a0cf0f70eb11e20
Source dataset
uspto-grants-1991_03
Patent number
US05001275

Reaction notes

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