Sodium Bicarbonate → HCID 14050787, compound

HRID 359631Notes

Reaction equation

HRID 359631 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:38]/[O:39][CH:40]([C:55]([OH:57])=[O:56])[C:41]2[CH:46]=[CH:45][C:44]([O:47]C(=O)C)=[C:43]([O:51]C(=O)C)[CH:42]=2)/[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[C@@H:12]2[S:13][CH2:14][C:15]([CH2:23][S:24][C:25]2[N:30]4[N:31]=[C:32]([C:34]([OH:36])=[O:35])[N:33]=[C:29]4[N:28]=[C:27]([CH3:37])[CH:26]=2)=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])[N:6]=1.C(=O)(O)[O-].[Na+]>O>[NH2:1][C:2]1[S:3][CH:4]=[C:5](/[C:7](=[N:38]/[O:39][CH:40]([C:55]([OH:57])=[O:56])[C:41]2[CH:46]=[CH:45][C:44]([OH:47])=[C:43]([OH:51])[CH:42]=2)/[C:8]([NH:10][C@@H:11]2[C:18](=[O:19])[N:17]3[C@@H:12]2[S:13][CH2:14][C:15]([CH2:23][S:24][C:25]2[N:30]4[N:31]=[C:32]([C:34]([OH:36])=[O:35])[N:33]=[C:29]4[N:28]=[C:27]([CH3:37])[CH:26]=2)=[C:16]3[C:20]([OH:22])=[O:21])=[O:9])[N:6]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 14050781HCID 14050781, compound

Product 1

HCID 14050787HCID 14050787, compoundYield 62.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The product obtained in Step 3 (0.25 g) was suspended in water (10 ml), and the pH of the mixture was adjusted to 8.0 with sodium bicarbonate. After stirring at room temperature for 6 hours, the resulting solution was applied to a Diaion HP 10 column. The objective fractions eluted with water were collected and lyophilized, giving 0.14 g of the objective compound (as sodium salt).

Workup

  1. washThe objective fractions eluted with water
  2. customwere collected

Sources & evidence

ORD record
ord-d10373155b604ca792e61f921d8569d7
Source dataset
uspto-grants-1991_03
Patent number
US05001121

Reaction notes

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