反应详情

温度

120 °C

A mixture of 4-fluorobenzaldehyde (12 ml) and 2-[N-methyl-N-(2-pyrimidinyl)amino]ethanol (10.05 g) in dry dimethyl sulphoxide (50 ml) containing anhydrous potassium carbonate (15 g) was stirred at 120° C. for 6 hours. The mixture was cooled to room temperature and added to water (200 ml). The aqueous solution was extracted with ethyl acetate (2×300 ml), the organic extracts washed with brine, dried (MgSO4) and evaporated. The title compound was obtained as an oil following chromatography on silica-gel in 2% methanol in dichloromethane.

1. temperatureThe mixture was cooled to room temperature
2. extractionThe aqueous solution was extracted with ethyl acetate (2×300 ml)
3. washthe organic extracts washed with brine
4. dry with materialdried (MgSO4)
5. customevaporated