Hydrogen Peroxide → HCID 178519689, compound

HRID 35973Notes

Reaction equation

HRID 35973 reaction equation
[O:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([NH:11][C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=2)[CH2:7][CH2:6]1)[N+:2]([O-:4])=[O:3].[OH:20]O>C(O)(=O)C>[O:1]([C@H:5]1[CH2:10][CH2:9][C@H:8]([NH+:11]([O-:20])[C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=2)[CH2:7][CH2:6]1)[N+:2]([O-:4])=[O:3]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 178523824HCID 178523824, compound

Product 1

HCID 178519689HCID 178519689, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
40 °C

Procedure

1.5 g (0.005 mol) N-(trans-4-nitroxycyclohexyl)nicotinic acid amide (Example 6/5) are dissolved in 4 ml acetic acid, 4 ml 30% hydrogen peroxide added thereto and stirred for 2 d at 40° C. After concentration and trituration with ethyl acetate, the crystals awe filtered off with suction. There remain 0.9 g of the title compound of the melting point 170°-171° C., i.e. 53% of theory.

Workup

  1. concentrationAfter concentration and trituration with ethyl acetate
  2. filtrationthe crystals awe filtered off with suction

Sources & evidence

ORD record
ord-fa02bf05af4c4fb3900569231f0c178d
Source dataset
uspto-grants-1995_05
Patent number
US05411989

Reaction notes

Loading…