N,N-Dimethylaminoethyl chloride hydrochloride → HCID 57181714, compound

HRID 359770Notes

Reaction equation

HRID 359770 reaction equation
[F:1][C:2]1[CH:29]=[CH:28][C:5]([O:6][C:7]2[CH:27]=[CH:26][C:10]3[NH:11][C:12](=[O:25])[C@H:13]([OH:24])[C@H:14]([C:16]4[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=4)[S:15][C:9]=3[CH:8]=2)=[CH:4][CH:3]=1.Cl.[CH3:31][N:32]([CH2:34][CH2:35]Cl)[CH3:33]>>[CH3:31][N:32]([CH3:33])[CH2:34][CH2:35][N:11]1[C:10]2[CH:26]=[CH:27][C:7]([O:6][C:5]3[CH:28]=[CH:29][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:8][C:9]=2[S:15][C@@H:14]([C:16]2[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=2)[C@@H:13]([OH:24])[C:12]1=[O:25]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 56977497HCID 56977497, compound

Product 1

HCID 57181714HCID 57181714, compound

Procedure

Following a procedure similar to that described in Example 11(d), 3,4 g of (2S, 3S)-2,3-dihydro-8-(4- fluorophenoxy)-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one [prepared as described in step (c) above] were alkylated with dimethylaminoethyl chloride hydrochloride to give 3.63 g of the title compound as a syrup.

Sources & evidence

ORD record
ord-9296f8f78c2f45af8b71df0446553890
Source dataset
uspto-grants-1991_03
Patent number
US05002942

Reaction notes

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