N,N-Dimethylaminoethyl chloride hydrochloride → HCID 57158223, compound

HRID 359771Notes

Reaction equation

HRID 359771 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:10]2[C@@H:16]([OH:17])[C:15](=[O:18])[NH:14][C:13]3[CH:19]=[CH:20][C:21]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:22][C:12]=3[S:11]2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].Cl.[CH3:31][N:32]([CH3:36])[CH2:33][CH2:34]Cl>>[CH3:31][N:32]([CH3:36])[CH2:33][CH2:34][N:14]1[C:13]2[CH:19]=[CH:20][C:21]([O:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)=[CH:22][C:12]=2[S:11][C@@H:10]([C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=2)[C@@H:16]([OH:17])[C:15]1=[O:18]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 57034745HCID 57034745, compound

Product 1

HCID 57158223HCID 57158223, compound

Procedure

Following a procedure similar to that described in Example 11(d), 400 mg of (2S, 3S)-2-(3-fluoro-4-methoxyphenyl)-2,3-dihydro-3-hydroxy- 8-phenoxy-1,5-benzothiazepin-4(5H)-one [prepared as described in step (c) aboVe] were alkylated with 2-dimethylaminoethyl chloride hydrochloride to afford 500 mg of the title compound as a syrup.

Sources & evidence

ORD record
ord-8fb17b41e22f400d80e931e175415647
Source dataset
uspto-grants-1991_03
Patent number
US05002942

Reaction notes

Loading…