N,N-Dimethylaminoethyl chloride hydrochloride → HCID 57210756, compound

HRID 359774Notes

Reaction equation

HRID 359774 reaction equation
[OH:1][C@H:2]1[C:8](=[O:9])[NH:7][C:6]2[CH:10]=[CH:11][C:12]([O:14][C:15]3[CH:20]=[CH:19][C:18]4[O:21][CH2:22][O:23][C:17]=4[CH:16]=3)=[CH:13][C:5]=2[S:4][C@H:3]1[C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=1.Cl.[CH3:33][N:34]([CH3:38])[CH2:35][CH2:36]Cl>>[CH3:33][N:34]([CH3:38])[CH2:35][CH2:36][N:7]1[C:6]2[CH:10]=[CH:11][C:12]([O:14][C:15]3[CH:20]=[CH:19][C:18]4[O:21][CH2:22][O:23][C:17]=4[CH:16]=3)=[CH:13][C:5]=2[S:4][C@@H:3]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][CH:25]=2)[C@@H:2]([OH:1])[C:8]1=[O:9]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 57321137HCID 57321137, compound

Product 1

HCID 57210756HCID 57210756, compound

Procedure

Following a procedure similar to that described in Example 11(d). 0.68 g of (2S, 3S)-2,3-dihydro-3-hydroxy- 2-(4-methoxyphenyl)-8-(3,4-methylenedioxyphenoxy)-1,5- benzothiazepin-4(5H)-one [prepared as described in step (c) above] was alkylated with 2-dimethylaminoethyl chloride hydrochloride to afford 0.72 g of the title compound as a gum.

Sources & evidence

ORD record
ord-3a133d1e28eb45e7a51d2a788887dfdd
Source dataset
uspto-grants-1991_03
Patent number
US05002942

Reaction notes

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