4-Methoxybenzaldehyde → 2-(4-Methoxyphenyl)-4-carbethoxy-5-methyloxazole N-oxide hydrochloride

HRID 359834Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]=[O:10])=[CH:7][CH:8]=1.[N:11](=[C:13]([C:19](=O)[CH3:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[OH:12].[ClH:22].COC1C=CC(C2OC(C)=C(C)[N+]=2[O-])=CC=1>>[ClH:22].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:19]([CH3:20])=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[N+:11]=2[O-:12])=[CH:5][CH:4]=1

Participants

Reactant 3

HCID 312444-Methoxybenzaldehyde

HCID 200640232-(4-methoxyphenyl)-4,5-dimethyloxazole N-oxide hydrochloride

HCID 178472877HCID 178472877, compound

Product 1

HCID 200641242-(4-Methoxyphenyl)-4-carbethoxy-5-methyloxazole N-oxide hydrochlorideYield 67%

Procedure

2-(4-Methoxyphenyl)-4-carbethoxy-5-methyloxazole N-oxide hydrochloride was prepared in 67% yield from anisaldehyde and ethyl 2-oximino-3-oxobutanoate according to the procedure of Example 89, part (a). The crude product was used directly in the next reaction.

Sources & evidence

ORD record: ord-2d96cdb1ec564dcc9b042175235c92bd
Source dataset: uspto-grants-1991_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05002960

Reaction notes

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